Complications. When esophagitis is not properly treated, health problems related to the structure and function of the esophagus can occur such as scarring, ulcers, and dangerous esophageal narrowing, which may be a serious medical emergency. Esophageal lining damage called Barrett's esophagus can occur with esophagitis which can result in precancerous tissue changes. In addition, untreated esophagitis can result in ulcers in the esophagus and esophageal perforations or holes in the esophagus. If an esophageal perforation or esophageal ulcer results from esophagitis, debris and food particles that become lodged in or around the lesion can result in a life-threatening infection that can spread into the blood. Chronic esophagitis increases the chances of developing cancerous growths in the cells of the esophagus lining because chronic acid exposure can cause mutations in the DNA of these cells.
